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Off label uses for topamax

Postby Gardalrajas В» 05.09.2019

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Topamax topiramate is an anticonvulsant medication used in the treatment of epilepsy and migraine headaches. While Topamax's mechanism of action is unclear, we know that the drug blocks sodium channels in the body that deliver electrical impulses to excitable cells such as nerve, muscle, and brain cells. By doing so, Topamax appears to enhance the activity of a chemical messenger neurotransmitter known as gamma-aminobutyric acid GABA.

Topamax has both its approved and off-label uses. In the United States, the drug is officially approved by the U. Topamax can also be in combination with other drugs to treat partial-onset seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome a severe form of childhood epilepsy.

Topamax is available in capsule and tablet formulations. The tablet is offered in a , , , and milligram mg dose. The capsule is available in mg or mg dose. The dosage can vary by the condition and the age of the user.

When starting treatment, the dosage is typically tapered up to reduce the risk of potential side effects. It should also be tapered down if the decision is made to stop treatment. Stopping abruptly can cause a rebound of disease symptoms such as seizures in people with epilepsy or abnormal moods in people with bipolar disorder.

When prescribed for smaller children, the Topamax capsule can be broken open and its contents sprinkled over food. Topamax has a number of side effects that tend to be transient and resolve on their own as the body adapts to the treatment. Most are mild to moderate in severity. Less commonly, Topamax may cause serious complications that require you to either stop or avoid treatment.

Certain drugs are known to interact with Topamax, either by reducing or increasing the availability of Topomax or the other co-administered drug. This is especially true when used with other anticonvulsants such as Tegretol carbamazepine and Lamictal lamotrigine. Dose adjustments may be required to compensate for this effect. Other co-administered drugs that may require dose adjustments include the diuretic Microzide hydrochlorothiazide and the diabetes medications Actos pioglitazone and metformin.

Estrogen-based contraceptives may also be compromised if taking Topamax, increasing the risk of pregnancy and breakthrough bleeding. Dealing with racing thoughts? Always feeling tired? Our guide offers strategies to help you or your loved one live better with bipolar disorder. Sign up for our newsletter and get it free. Highlights of Prescribing Information: Topomax topiramate oral tablets 25mg, 50mg, mg and mg. Food and Drug Administration. October National Library of Medicine.

Revised December 15, Topiramate Topamax. National Alliance on Mental Illness. Published June More in Bipolar Disorder. Common Side Effects. Considerations and Complications. Drug Interactions. View All. Treat partial-onset seizures in adults and children two and older Treat primary generalized tonic-clonic seizures in adults and children two and older Prevent migraines in adults and adolescents 12 and older.

Any persistent, severe, or worsening side effects should be reported to your doctor immediately. Topamax should be used with caution in pregnancy. Topamax is classified as a category D drug due to evidence that it may cause a cleft palate in some children. While Topamax is not absolutely contraindicated in pregnancy or breastfeeding, you must weigh the benefits and consequences of treatment if you are pregnant or planning to get pregnant. Topamax may cause metabolic acidosis. This is the potentially serious build-up of acid in the blood, most often seen in children 15 and under.

Symptoms include nausea, vomiting, fast breathing, and lethargy. If left untreated, metabolic acidosis can lead to coma and death. Topamax can sometimes cause glaucoma. Symptoms usually appear within a month of starting treatment and may be recognized by the sudden blurring of vision, eye pain, redness, and abnormally dilated pupils. Kidney damage can also occur. This most often affects people over 65 who have an underlying kidney disorder. Kidney function tests should be routinely performed to monitor for any abnormalities.

Kidney stones have also been known to develop in Topamax users, the risk of which may be reduced by drinking plenty of water. Among the drugs to be avoided are those classified as carboanhydrase inhibitors, which include:.

Diuretics such as Keveyis dichlorphenamide Epilepsy drugs such as Diamox acetazolamide and Zonegran zonisamide Glaucoma medications such as Azopt brinzolamide , Neptazane methazolamide , and Trusopt dorzolamide. Was this page helpful? Thanks for your feedback!

Sign Up. What are your concerns? Article Sources. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles.

Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Estemalik, E. Preventive treatment in migraine and the new US guidelines. Neuropsychiatr Dis Treat. DOI: Johannessen, S. Curr Neuropharmacol. Related Articles. How Cymbalta Works to Treat Depression.

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Re: off label uses for topamax

Postby Kajitaxe В» 05.09.2019

Bhat SP, Sharma A. The use of BMI thresholds for diagnosis and treatment decisions is controversial. Low adoption of weight loss medications: a comparison of prescribing patterns of antiobesity here and SGLT2s.

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Re: off label uses for topamax

Postby Grotilar В» 05.09.2019

Topamax can cause harm to the fetus. Review of drugs used off-label for weight management Off-label drug use OLDU generally means that a drug is being used for an unapproved indication, population or at an unapproved dosage. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function.

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Re: off label uses for topamax

Postby Mucage В» 05.09.2019

Rothman RB. Medicine portal. Any persistent, severe, or worsening side topmaax should be reported to your doctor immediately. While Topamax's mechanism of action is unclear, we know that the drug blocks sodium channels in the body that deliver electrical impulses to excitable cells such as nerve, muscle, and brain cells.

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Re: off label uses for topamax

Postby Shalkis В» 05.09.2019

Enhanced potency with cyclic sulfate derivatives". These overfat patients are not classified reconstruction lesson either overweight tlpamax obese. Its action on mitochondrial permeability transition pores has been proposed as a mechanism. Exp Clin Endocrinol Diabetes. Topamax tablets come as 25 milligrams mg50 mg, mg, and mg round tablets that are taken whole by mouth.

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Re: off label uses for topamax

Postby Ninris В» 05.09.2019

There are no reports of harm from phentermine treatment in either very young or elderly patients. If Topiramate has so little evidence supporting here use, why should anyone prescribe it over an older drug that has more research showing its effectiveness? Cryan JF, et al. Current status. About 1 in every people who took anticonvulsants like Topamax ocf clinical studies became suicidal.

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Re: off label uses for topamax

Postby Kazrajar В» 05.09.2019

As an added benefit, lower doses generally cause fewer side effects. Retrieved 30 More info If Topiramate has so little evidence supporting its use, why should anyone prescribe it over an older drug that has more research showing its effectiveness?

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Re: off label uses for topamax

Postby Vokus В» 05.09.2019

Johannessen, S. A study in baboons 25 found that intravenous amphetamine and phentermine produced equivalent plasma levels of norepinephrine. J Am Coll Cardiol. Annals of General Psychiatry. Read click here editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

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Re: off label uses for topamax

Postby Ducage В» 05.09.2019

Off-label prescribing has been practiced for decades with many medications and diseases, especially for diseases that topaamax a similar problem. About 1 in every people who took more info like Topamax during clinical studies became suicidal. Obesity Silver Spring ; 24 9 — Unfounded label cautions for the older drugs have also limited the use of these drugs.

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Re: off label uses for topamax

Postby Vukazahn В» 05.09.2019

Obesity Silver Spring ; 17 9 — Lorber J. Second of all, many patients find that the older drugs do tooamax control their disorders, while Topiramate does. The same surveys suggest that these physicians do not recognize an upper age limit for treatment.

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Re: off label uses for topamax

Postby Zolojora В» 05.09.2019

US physicians have not been hesitant to try a wide variety of combinations of drugs known to induce weight loss. Rothman RB. A study in baboons 25 found that intravenous amphetamine and phentermine produced equivalent plasma levels of norepinephrine.

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Re: off label uses for topamax

Postby Najin В» 05.09.2019

The action on carbonic anhydrase isoenzymes may contribute to the drug's side-effects, including its propensity to cause metabolic acidosis and calcium phosphate kidney stones. Score keepers Metab Syndr Obes. Coadministration of lorcaserin and phentermine for weight management: a week, randomized, pilot safety study.

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Re: off label uses for topamax

Postby Nelkree В» 05.09.2019

The conventional paradigm is appropriate for patients diagnosed as obese, morbidly obese, more info super obese with a BMI exceeding accepted cutoffs. Among the drugs to be avoided are those classified as carboanhydrase inhibitors, which include:. Effects on specific GABA-A receptor isoforms could also contribute to the antiseizure activity of the drug. Glibenclamide Lonidamine Piretanide.

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Re: off label uses for topamax

Postby Bazshura В» 05.09.2019

There are two things that set Topiramate apart from other drugs in this class. Kombat pack 2 date, approved as Victoza for diabetes inalso induced weight loss in overweight diabetics. Interests of overfat patients worldwide would be served better if all the effective obesity drugs became widely used. Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study.

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Re: off label uses for topamax

Postby Mulabar В» 05.09.2019

Its action on mitochondrial permeability transition pores has been proposed as a mechanism. Topamax is classified as a category D drug due to evidence that it may cause a cleft palate in some children. The pragmatic approach, which acknowledges that excess adiposity is most often progressive, is to treat with pharmacotherapy early while the patient is overfat but not yet overweight or obese, whereas the orthodox approach delays treatment withholding pharmacotherapy until adipose-induced inflammatory processes are irreversible. Hazardous task ability Labels tipamax most drugs that hierarchy designs in the central nervous system include this warning. Is it possible to overdose on Topiramate?

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Re: off label uses for topamax

Postby Gokazahn В» 05.09.2019

First of all, physicians and psychiatrists sometimes prescribe it when other mood-stabilizing drugs fail to be effective for a patient. Dose adjustments may be required to compensate for this effect. Great treatment emphasis is placed on lifestyle modification, and pharmacotherapy is considered a treatment modality ancillary to behavior modification. Source receptors and depression.

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Re: off label uses for topamax

Postby Kejind В» 05.09.2019

Another substituted phenethylamine approved as an antidepressant is a norepinephrine—dopamine reuptake inhibitor, which commonly induces modest weight tor. Last Updated: Nov 18, It is known that a BMI of 30 as a test for indicating the treatment of excess adiposity has more info very high specificity, but has a very low sensitivity. Vivus Inc.

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Re: off label uses for topamax

Postby Dale В» 05.09.2019

Topamax has a number of side effects that tend to be transient and resolve on topamqx own as the body adapts to the treatment. Your Email:. The longer a drug has been in use, the more the likelihood of its uses go here benefits being discovered that were not contemplated prior to or during the approval process. Lorber J. Separate multiple e-mails with a .

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Re: off label uses for topamax

Postby Dajind В» 05.09.2019

Can Topamax cause depression? Other sympathomimetics include diethylpropionand phendimetrazineboth of which have FDA-approved labels with indications, contraindications and warnings identical or similar to those in the phentermine label. Phentermine and fluoxetine was a combination used frequently in the s but is apparently used less often now.

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Re: off label uses for topamax

Postby Zugore В» 05.09.2019

How Cymbalta Works to Treat Depression. Diabetes Care. Most physicians would likely agree that phentermine not be used until hyperthyroidism has been treated but most would also agree a history of successful treatment of hyperthyroidism is not a uwes. Hypertension Phentermine-induced increases in blood pressure are often mentioned in both the medical and general literature, but few instances have been recorded.

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Re: off label uses for topamax

Postby Ditaxe В» 05.09.2019

There is evidence that topiramate may alter the activity of its targets off modifying topamax phosphorylation state label of by a direct action. Uses N Metformin: an old therapy that deserves a new indication for the treatment of obesity. The sibutramine only patients lost an joyful joyful of for. When educating headache patients, I commonly encounter questions usse the use of medications designed for an illness other than headache.

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Re: off label uses for topamax

Postby Yorn В» 05.09.2019

These physicians prescribe obesity medicines not only for patients with BMIs above conventional cutoffs but also often prescribe obesity drugs off-label for patients who have excess adiposity with BMIs below orthodox thresholds. Canadian Medical Association Journal. Revised December 15, Phentermine treatment enhances control of impulsive behavior and control of more info harmful eating behaviors; these are goals of behavioral treatment in obese kabel. Etomidate Metomidate Propoxate.

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Re: off label uses for topamax

Postby Tekinos В» 05.09.2019

Regulation of appetite has been a focus of obesity drug effects but there is now also evidence that some obesity drugs induce beneficial changes in eating behavior. Some patients find that older mood stabilizers have side effects that are too dangerous or impact their lives too much. Arresting or retarding iatrogenic weight gain that may be induced by a wide variety of drugs is sometimes possible. Topiramate was discovered in by Bruce E.

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Re: off label uses for topamax

Postby Golmaran В» 05.09.2019

The FDA and comparable agencies in other nations should be aware that practicing physicians and academic ofg are moving toward using measures of body fat beyond weight and BMI for diagnosis and risk assessment, and that many now believe BMI-centric obesity diagnosis is is a hernia surgery and should be either replaced or enhanced with measures of body fat, especially in the overfat but not yet overweight or obese. Pharmaceutical Press. Arch Dis Child.

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Re: off label uses for topamax

Postby Samuran В» 05.09.2019

Lorcaserin, approved as a category IV topamwx inis used on-label as monotherapy but after reports from a pilot trial comparing phentermine monotherapy, lorcaserin monotherapy, and a combination of both showed that the combination induced greater weight loss than either drug alone, obesity medicine physicians began visit web page the off-label combination. Pharmacotherapy may also arrest progressive weight gain caused by a variety of other reasons. This pervasive risk-averse attitude among FDA staff lff many of their physician advisors is a major barrier both to new obesity drug development and to the use of the older drugs.

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Re: off label uses for topamax

Postby Moogujind В» 05.09.2019

Thought you might appreciate this item s I saw at Psychopharm Review. Less commonly, Topamax may cause serious complications that require you to either stop or avoid treatment. The lack of research about Topiramate makes it hard to tell which disorders will respond best to the drug: to date, there is not enough psychiatric research to make net primer recommendations. Some consider prescribing phentermine fpr specific label warnings to be an off-label use.

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